Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count

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About This Item

Details

  • The only veterinary supplement formulated with alpha-casozepine, a natural ingredient from cow’s milk with calming properties to help relax cats and dogs.
  • Non-drowsy formula provides a sense of calm and contentment without tranquilizing or sedating your pal.
  • Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.
  • Free of lactose and preservatives, so it’s ideal for pets with sensitive tummies; used by veterinarians and animal behaviorists worldwide.
  • Formula comes in 75 mg capsules that can be given by mouth, or opened and mixed with a meal.

Ingredient Information

Instructions

FAQ

Learn More About Vetoquinol From Our Team of Experts

Compare Similar Items

Vetoquinol
Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
Vetoquinol
Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count
$37.99 Chewy Price
($1.27/ea)
Rated 4.1 out of 5 stars
843Reviews
Flavor           
Chicken
Chicken
Fruits & Vegetables
Liver, Meat
Peanut Butter, Carob
Chicken
Bacon
Chicken, Poultry
Breed Size           
Small Breeds
All Breeds
All Breeds
All Breeds
All Breeds
All Breeds
All Breeds
All Breeds
Small Breeds
All Breeds
Small Breeds
All Breeds
Packaging Type           
Tub
Bag
Bag
Bag
Bag
Tub
Pouch
Bag
Pouch
Bag
NASC Certified           
Yes
Yes
Yes
Yes
Yes
No
Yes
Yes
Yes
Yes
Made In           

Questions & Answers

28 Customer Questions


Are any of the ingredients made or obtained from China? Where is this manufactured?

Answer by ChewyNov 07, 2019
This product is sourced in Canada and manufactured in the USA.

I'm moving and am taking my 2 cats and 3 dogs with me.. would this help them for an 18 hour drive?

Answer by ChewySep 20, 2018
This is perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.

How long will the supplement last after administered?

Answer by ChewyJul 24, 2019
On average, Zylkene will take effect in 1-2 hrs. Keep in mind that the age, sex, and basal metabolism will affect the onset time. These same factors will also influence how long it lasts as well.

How much melatonin is in each capsule?

Answer by ChewyDec 23, 2019
This supplement does not contain Melatonin. For a complete list of ingredients, click on the 'Nutritional Info' tab, next to the 'Description' tab, just under the product photos.

4.1
Rated 4.1 out of 5 stars
843 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Effectiveness

74% Positive

Form and Administration

79% Positive

Ingredients

78% Positive

Nutritional Value

73% Positive

524 Customer Reviews



Rated 5 out of 5 stars
By Lindsay on Oct 3, 2025

Helped more than I thought it would!

Zyklene helped my anxious kitty after we added a new kitten to the family. She is also taking gabapentin and Fluoxetine, bit the Zylkene seems to have a fast and

Zyklene helped my anxious kitty after we added a new kitten to the family. She is also taking gabapentin and Fluoxetine, bit the Zylkene seems to have a fast and noticeable effect. She's so much more relaxed and playful, and her litter box accidents have nearly stopped. She's a very picky eater (usually won't eat any supplements, even in her favorite wet food), but she eats the Zylkene with no problem. I just make sure to stir it in really really well. It's worth a try if you are considering it, especially in combination with anti anxiety medications.


Rated 2 out of 5 stars
By Aleksandra on Sep 17, 2025

Not helping with anxiety.

I got these for our 3 year old boy who is very skittish and anxious. I’ve been looking around at calming supplements for him because I want to find something that

I got these for our 3 year old boy who is very skittish and anxious. I’ve been looking around at calming supplements for him because I want to find something that will help him before we have to turn to Fluoxetine which his vet has already prescribed. We also have Feliway diffusers so I thought with an added supplement maybe we could see some changes but we haven’t noticed much of a difference. I’m going to continue making him a few safe spaces in our apartment where he can hide out in if anxious and see if there are any improvements but as for the supplement we are not having any luck.


Rated 4 out of 5 stars
By Laura on Oct 4, 2025

Dachshund

I’ve got this for my dachshund who can be anxious when we have guests over. It helps him mellow out a little bit when given regularly before a big event. It’s a

I’ve got this for my dachshund who can be anxious when we have guests over. It helps him mellow out a little bit when given regularly before a big event. It’s a fix it all though still use training with this product to see actual results with you dog.


Rated 5 out of 5 stars
By Alexandria on Aug 24, 2025

No more floor poops!

Started Zylkene to see if it would help one of my cats as he was often pooping on the floor - even doing it when I was sitting in the room. Within weeks of starting

Started Zylkene to see if it would help one of my cats as he was often pooping on the floor - even doing it when I was sitting in the room. Within weeks of starting the Zylkene with his breakfast his floor pooping has gone down to maybe once a month and I’ve confirmed with his vet that it must be stress (ie me not coming home early enough in the evenings) and now I don’t have to worry that he has some hard to diagnose GI issue.


Rated 5 out of 5 stars
By Emily on Sep 3, 2025

Works well for us

Calms my hyperactive kitty at night so he can get a little sleep. I like that it is Not a drug it is a supplement. He has an easy time waking up so it’s not like

Calms my hyperactive kitty at night so he can get a little sleep. I like that it is Not a drug it is a supplement. He has an easy time waking up so it’s not like giving him a sleeping pill it just helps calm him down a little bit at night. No over sedation. It’s mild for him.


Rated 5 out of 5 stars
By Jeanne on Aug 27, 2025

Easy on the stomach

This product helped to ease the anxiety in both of my elderly dogs. One of them has a very sensitive stomach and I was afraid it would make her sick. I am so pleasantly

This product helped to ease the anxiety in both of my elderly dogs. One of them has a very sensitive stomach and I was afraid it would make her sick. I am so pleasantly surprised that she has been able to tolerate it! My vet recommended this product and I am so happy that I tried it.


Rated 2 out of 5 stars
By Bean on Sep 20, 2025

Didn't help anxious cat

No luck on either one or two pills helping our anxious cat (just under the 10lb dosing difference). But I think she might need prescription medication, and this

No luck on either one or two pills helping our anxious cat (just under the 10lb dosing difference). But I think she might need prescription medication, and this might help a moderately anxious cat.


Rated 5 out of 5 stars
By Ann on Aug 20, 2025

Easing the transition for a new kitty

I was really impressed and surprised by just how well these supplements helped settle my new kitty Boo in her transition from street life to an indoor home. I'm

I was really impressed and surprised by just how well these supplements helped settle my new kitty Boo in her transition from street life to an indoor home. I'm hoping to ease introductions to the 3 resident cats that she initially tried to kill.


Rated 4 out of 5 stars
By Dave on Aug 16, 2025

Picky eater won't touch

Tried to give this to my anxious cat for when I moved apartments. She wouldn't touch it no matter how hard I tried. Eventually just let the other cat eat her food

Tried to give this to my anxious cat for when I moved apartments. She wouldn't touch it no matter how hard I tried. Eventually just let the other cat eat her food. Hard to evaluate the efficacy when she refused to eat it. Worth a shot.


Rated 1 out of 5 stars
By Travis on Jul 12, 2025

It sounded promising but didn’t work.

My two cats were having behavioral issues that caused stress and anxiety. I spoke to the chat with a vet at chewy and they recommended this. I did not have any wet

My two cats were having behavioral issues that caused stress and anxiety. I spoke to the chat with a vet at chewy and they recommended this. I did not have any wet cat food and bought a small box and mixed this in their food. One cat would eat all of the food and the pills that were sprinkled in, the other cat would eat 30-40% of the food (I am not sure if he doesn’t like the food or can taste the powder) and may have not received the full amount of pill powder. So far after 4 days of use I have not seen any change in behavior. The big cat still is aggressive sometimes and bullies the little cat. The little cat still is skittish and anxious. Their behavior is the same if they are taking the supplement or not taking it. The bottle doesn’t seem to last as long as it says to give them 2 capsules per day so a 30 count bottle will only last around 2 weeks and with two cats it will only last a week. I other people’s reviews and I am glad it worked for their cats, however it did not work for mine.