Vetoquinol Zylkene Capsules Calming Supplement for Dogs, 30 count

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About This Item

Details

  • The only veterinary supplement formulated with alpha-casozepine, a natural ingredient from cow’s milk with calming properties to help relax dogs.
  • Non-drowsy formula provides a sense of calm and contentment without tranquilizing or sedating your dog.
  • Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.
  • Free of lactose and preservatives, so it’s ideal for dogs with sensitive tummies; used by veterinarians and dog behaviorists worldwide.
  • Formula comes in 450 mg capsules that can be given by mouth, or opened and mixed with a meal.

Ingredient Information

Instructions

FAQ

Learn More About Vetoquinol From Our Team of Experts

Compare Similar Items

Vetoquinol
Zylkene Capsules Calming Supplement for Dogs, 30 count
Vetoquinol
Zylkene Capsules Calming Supplement for Dogs, 30 count
$84.99 Chewy Price
($2.84/ea)
Rated 3.8 out of 5 stars
190Reviews
Flavor    
Unflavored
Chicken
Breed Size    
Large Breeds, Giant Breeds
All Breeds
All Breeds
All Breeds
Medium Breeds, Large Breeds
Packaging Type    
Bag
Bag
Bag
Tub
NASC Certified    
Yes
Yes
Yes
Yes
Yes
Made In    

Questions & Answers

9 Customer Questions


will this make my dog less playful and get deprest

Answer by ChewyApr 19, 2018
This supplement will not cause your dog to be depressed. The non-drowsy formula uses alpha-casozepine, a natural ingredient found in cow’s milk, to help balance the stress reactions of dogs safely and with no tranquilizing or sedating effects.

Generally speaking, how long is a Zylkene capsule effective in a dog? There are chews available that work for about four hours, and I am looking for something that will assist a bit longer in the day. Thank you.

Answer by ChewySep 10, 2018
The results will vary from pet to pet, but generally speaking the effects last most of the day (4+ hours).

My vet prescribed one pill 1-2 hours before the car ride that stresses my dog out. I’m reading that it should be days, not hours?

Answer by ChewyJul 11, 2019
This dog supplement recommends dogs 33 - 65 pounds to have 1 capsule daily. For dogs 66 - 132 pounds, feed 2 capsules daily. We recommend consulting your Veterinarian to see what would be a good fit for your pet.

Can this be used with fluoxetine and other prescription meds given for anxiety?

Answer by ChewyNov 27, 2018
While this is formulated with natural ingredients, you would need to check with your vet or the warnings for the specific medications to see if these can be taken together.

3.8
Rated 3.8 out of 5 stars
190 Ratings

148 Customer Reviews



Rated 4 out of 5 stars
By Andra on Jul 3, 2025

Happy pup

While this supplement seems to have a positive effect on my 70 lb rescue hound, unfortunately the cost is an issue because she needs the large dog dosage:( I tried

While this supplement seems to have a positive effect on my 70 lb rescue hound, unfortunately the cost is an issue because she needs the large dog dosage:( I tried a lower dose and it didn’t have the same effect. Misty has been seen by several vets that cannot find anything wrong but she continues to be very needy and is constantly pawing me for attention.


Rated 1 out of 5 stars
By Gary on Jul 23, 2025

Didn’t calm my dog

Didn’t calm my dog at all. Don’t waste your money on this

Didn’t calm my dog at all. Don’t waste your money on this


Rated 2 out of 5 stars
By Kathy on Jan 17, 2025

No visible results!!

I used this for 3 months and saw no improvement in mood & agitation. After trying everything for 2yrs the veterinarian put him on Prozac and that did the trick!

I used this for 3 months and saw no improvement in mood & agitation. After trying everything for 2yrs the veterinarian put him on Prozac and that did the trick!!


Rated 5 out of 5 stars
By Ray on Feb 24, 2025

The speed of delivery.

The delivery was quick and accurate.

The delivery was quick and accurate.


Rated 1 out of 5 stars
By Kent on Sep 3, 2024

Pointless

I have a nervous female pitbull. My vet recommended this as a possible addition to her various supplements. I noticed absolutely no difference in her behavior or

I have a nervous female pitbull. My vet recommended this as a possible addition to her various supplements. I noticed absolutely no difference in her behavior or mood.


Rated 2 out of 5 stars
By Derri on Nov 23, 2024

Did nothing for our anxious dog

Might work for others but did not for us,

Might work for others but did not for us,


Rated 3 out of 5 stars
By 2g7sy4y4vz on Oct 9, 2024

How $$$ it’s become!

It helps anxiety in animals, but it shouldn’t cost so much

It helps anxiety in animals, but it shouldn’t cost so much


Rated 2 out of 5 stars
By Dee on Apr 10, 2024

My mini goldendoodle has been taking this daily for 2 weeks now. I am not seeing any calming of her behavior. I will continue for the month but this med is EXTREMELY

My mini goldendoodle has been taking this daily for 2 weeks now. I am not seeing any calming of her behavior. I will continue for the month but this med is EXTREMELY expensive and I will not re order if I don’t see some type of anxiety reduction


Rated 5 out of 5 stars
By Donna on Aug 19, 2024

Works great!

Calms my dog's anxiety and helps her to rest.

Calms my dog's anxiety and helps her to rest.


Rated 1 out of 5 stars
By terriergal on Sep 13, 2024

Did nothing

Did nothing at all.

Did nothing at all.